DOI is Unscheduled in the United States. That said, it may possibly be considered an analogue of a Schedule I drug.

Addictive Potential: Unknown

Emergency Room Visits Yearly: No recorded hospital visits

Mandatory Minimum Sentence: Unknown

Mechanism of Action: selective 5-HT(2A), 5-HT(2B), and 5-HT(2C) receptor partial agonist



2,5-dimethoxy-4-iodoamphetamine (DOI) is a psychedelic drug and a substituted amphetamine of the phenethylamine family. Despite being a substituted amphetamine, it is not a stimulant.

When ingested recreationally, DOI is active at a dosage of 1.5 - 3.0mg (orally) and has a duration of 16 - 30 hours (approximately twice as long as LSD). DOI's effects have been compared to LSD, although there are differences that experienced users can distinguish. Besides the longer duration, the trip tends to be more energetic than an LSD trip, with more body load and a different subjective visual experience. The after effects include residual stimulation and difficulty sleeping, which, depending on the dose, may persist for days.

DOI is often sold as a substitute for LSD, or even sold falsely as LSD, which may be dangerous because DOI does not have the same established safety profile as LSD. Unlike LSD, the psychedelic amphetamines (including DOI) can have harmful and potentially fatal physical effects in overdose. Although there have been no known deaths due to DOI ingestion, it is relatively new on the recreational scene so long-term effects are not known.


Lsd Blotter Acid Mimics:

According to the DEA (2008) , "The Palm Beach County Sheriff’s Office Crime Laboratory Chemistry Section (West Palm Beach, Florida) recently received two different exhibits of blotter paper, suspected LSD (no photos). The exhibits were seized in Lantana (about 5 miles south of Palm Beach) by the Lantana Police (no further details). The first exhibit consisted of one-quarter inch square of blotter paper, orange on one side and blank on the other; analysis by Erlichs (negative), GC, and GC/MS indicated not LSD but rather 4-iodo-2,5-dimethoxyamphetamine (DOI). The second exhibit consisted of a rectangular piece of blotter paper, blank on both sides and perforated into three quarter-inch squares; analysis (same techniques) indicated not LSD but rather 4-chloro-2,5-dimethoxyamphetamine (DOC). The exhibits were not formally quantitated, but both had a high loading based on their GC chromatograms. This was the first ever submission of DOI in any form, and the third submission of DOC on blotter paper, to the laboratory."


Side Effects and Adverse Reactions:

DOI is a research chemical. Research chemicals are experimental chemicals that are not approved for human consumption. This is because not enough data exists currently about their side effects, adverse reactions, long term damage, addiction potential, etc. Although some people are willing to ingest research chemicals, it is not reasonable to assume that they are in any way safe to use recreationally.





DOI Entry from PiHKAL

Extra-strong new LSD-type hallucinogenic drug hits Adelaide

New drug alert as three taken ill



The NeuroSoup Trip Guide - The free e-book version of The Neurosoup Trip Guide is now available online. It contains chapters on Choosing the Right Hallucinogen; Set, Setting, and Preparation for a Trip; Tips for Tripsitters; Aspects of the Entheogenic Experience; Working with Difficult Experiences; Integration; and References and Recommended Reading.


More Info:

Trip Report Project

How to Work With Bad Trips