JWH-018 was emergency scheduled into schedule I category on March 1, 2011 in the United States. It is illegal in several States, including Alabama, Arkansas, Georgia, Kentucky, Kansas, Louisiana, North Dakota, and Tennessee.

Addictive Potential: Unknown

Emergency Room Visits Yearly: Unknown

Mandatory Minimum Sentence: Unknown

Mechanism of Action: Cannabinoid receptor agonist



JWH-018 (1-pentyl-3-(1-naphthoyl)indole) is an analgesic chemical from the naphthoylindole family, which acts as a full agonist at both the CB1 and CB2 cannabinoid receptors, with some selectivity for CB2.  JWH-018 is used in basic scientific research to identify cannabinoid receptors in the brain and study Δ9-THC’s mechanisms of action. According to the DEA (2009), "Based on the structural analysis, JWH-018 is not categorized as a THC substance, and is not similar in chemical structure to other substances controlled under the CSA." The average dose is around 2-5mg smoked and the effects usually last for 1-3 hours.

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Side Effects and Adverse Reactions:

JWH-018 is a research chemical. Research chemicals are experimental chemicals that are not approved for human consumption. This is because not enough data exists currently about their side effects, adverse reactions, long term damage, addiction potential, etc. Although some people are willing to ingest research chemicals, it is not reasonable to assume that they are in any way safe to use recreationally.


JWH-018 and Drug Tests:

JWH-018 can be detected with drug tests from the redwood toxicology laboratory. The test checks for JWH-018 and JWH-073 metabolites in the urine with a window of detection up to 72 hours (depending on usage/dosage).


Experience Reports:

JWH-018 Experience #1

JWH-018 Experience #2

JWH-018 Experience #3

JWH-018 Experience #4

JWH-018 Experience #5

JWH-018 & Alcohol Experience






JWH-018 in Drugs and Chemicals of Concern (DEA Website)

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The NeuroSoup Trip Guide - This e-book discusses: Set, Setting, and Preparation for a Trip, Tips for Tripsitters, Aspects of the Entheogenic Experience, Working with Difficult Experiences, and Integration. Adverse psychological reactions, like flashbacks and HPPD, may potentially be avoided with proper preparation before and integration after entheogenic journeys. Thus, this e-book serves the purpose of harm reduction education. For clarity, NeuroSoup does not advocate the use of illegal, quasi-legal, or legal drugs. All substances that affect the central nervous system (legal or illegal) can have side effects, adverse reactions, and negative interactions with other drugs. Abstinence is always the best way to protect one's health.


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