Nabilone (Cesamet)

Nabilone is Schedule II in the United States.

Addictive Potential: Low

Emergency Room Visits Yearly: Unknown

Mandatory Minimum Sentence: Unknown

Mechanism of Action: Cannabinoid receptor agonist

 

Overview:

Nabilone is a synthetic cannabinoid with therapeutic use as an antiemetic and as an adjunct analgesic for neuropathic pain. It is a synthetic cannabinoid, which mimics the main ingredient of cannabis (THC). Chemically, nabilone is similar to the active ingredient found in naturally occurring Cannabis sativa L.

In Canada, the United States, the United Kingdom and Mexico, nabilone is marketed as Cesamet. It was approved in 1985 by the U.S. Food and Drug Administration (FDA) for treatment of chemotherapy-induced nausea and vomiting that has not responded to conventional antiemetics. Though it was approved by the FDA in 1985, the drug only began marketing in the United States in 2006. It is also approved for use in treatment of anorexia and weight loss in patients with AIDS.

Although it doesn't have the official indication (except in Mexico), nabilone is widely used as an adjunct therapy for chronic pain management. Numerous trials and case studies have demonstrated various benefits for condition such as fibromyalgia and multiple sclerosis.

*View and Submit Your Experiences in the New Community Trip Reports Area*

 

Side Effects and Adverse Reactions:

During controlled clinical trials of Cesamet, virtually all patients experienced at least one adverse reaction. The most commonly encountered events were drowsiness, vertigo, dry mouth, euphoria (feeling “high”), ataxia, headache, and concentration difficulties.

 

Research:

CESAMET™ (nabilone) Fact Sheet

 

E-books:

The NeuroSoup Trip Guide - This e-book discusses: Set, Setting, and Preparation for a Trip, Tips for Tripsitters, Aspects of the Entheogenic Experience, Working with Difficult Experiences, and Integration. Adverse psychological reactions, like flashbacks and HPPD, may potentially be avoided with proper preparation before and integration after entheogenic journeys. Thus, this e-book serves the purpose of harm reduction education. For clarity, NeuroSoup does not advocate the use of illegal, quasi-legal, or legal drugs. All substances that affect the central nervous system (legal or illegal) can have side effects, adverse reactions, and negative interactions with other drugs. Abstinence is always the best way to protect one's health.

 

More Info:

List of Synthetic Cannabinoids

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